Rennae represented Australia for four successive Olympics; Atlanta 1996, Sydney 2000, Athens 2004 and Beijing 2008. She has recorded more doubles victories (60) from 1992 to 2010 on the WTA Tour than any other Australian woman. She was ranked No. 1 in the world in Women's Doubles in 2000 and in 2001, won the season ending WTA Championships with partner Lisa Raymond and named ITF World Champions. She owns 5 Grand Slam Doubles Titles, 2000 Australian Open Women's and Mixed Doubles, 2001 Mixed and Women's U.S. Open Doubles, and Wimbledon Women's Doubles Champion 2004. Rennae was also a French Open Mixed and Women's Doubles finalist in 2000. Rennae is the longest serving member of the Australian Fed Cup Team and retired from her tennis career in 2011.

Rennae is a television color commentator for The Tennis Channel and Australian television.